Recurrent Implantation Failure (RIF) is a major issue of infertility that is still not fully understood, even after transferring good quality embryos. In order for the uterus to receive an embryo, the interior of the uterus known as endometrium must be ready in the right timing, calculated in coordination with the body's menstrual cycle. This is known as window of implantation. For some women, this timing can be different and this altered timing of the window of implantation could be one of the reasons where embryos fail to implant despite transferring the best embryo.
Recently, a Spanish team has developed a test called Endometrial Receptivity Analysis (ERA) that is able to detect a receptive endometrium with the use of specific transcriptomic signature. It identifies endometrial receptivity, the optimal time for embryo transfer that is specific for each woman, known as personalised embryo transfer.
ERA was then made available in Alpha IVF in early 2018 and recently, Alpha IVF conducted an initial experience study with the ERA on a group of IVF patients with a history of recurrent implantation failure and their clinical outcome after personalised frozen embryo transfer.
You can click here to read more from the abstract.
How does it benefit a patient?
From the study, Alpha IVF showed that patients with recurrent implantation failure achieved good clinical pregnancy (CPR) and implantation rates (IR) when they had their embryo(s) transferred following the correct window of implantation.
Endometrial receptivity analysis (ERA) reveals the true timing of window of implantation and enables our fertility consultant to alter the embryo transfer time based on individual optimum window of implantation .This study was accepted for the 10th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE) that will happen on 4th-7th August 2020, in Manila, Philippines.