PGT-M – Preimplantation Genetic Testing for Monogenic Diseases

What is PGT – M?

PGT – M enables couples with an inheritable genetic condition in their family to avoid passing it on to their children. It is a powerful test performed prior to implantation to help identify single gene defects within embryos created through IVF to avoid conceiving a child with a genetic disorder.

Preparation or a set up test may be necessary prior to starting a PGT – M cycle. Most of the time, blood samples from the couple are required and all tests must be scheduled in advance and coordinated through Alpha IVF & Women’s Specialists Genetics Services Team.

Indications for PGT – M

Your physician may recommend PGT – M if :

  • You have previous pregnancy termination(s) because of a serious genetic condition
  • You already have a child with a serious genetic condition
  • You have a family history of a serious genetic condition, or
  • You have a family history of chromosome problems.

Examples of some common single gene disorders

Alpha thalassemia Hemophilia A & B
Beta thalassemia Duchene muscular dystrophy
Cystic fibrosis Becker’s muscular dystrophy
Spinal muscular atrophy Glucose – 6 – phosphate dehygenase deficiency
Sickle cell disease

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