Understanding PGT-A: How Preimplantation Genetic Testing Improves IVF Success

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For couples undergoing IVF, ensuring the best possible chances of a successful pregnancy is a top priority. One major factor influencing embryo viability is chromosomal health. PGT-A (Preimplantation Genetic Testing for Aneuploidies) is a screening technique that helps select embryos with the correct number of chromosomes, reducing the risk of implantation failure and miscarriage.

If you are considering IVF and want to optimise your chances of success, consulting with top fertility specialists in Kuala Lumpur can provide valuable insights into whether PGT-A is right for you.

How Chromosomal Abnormalities Impact Fertility

Embryos with chromosomal abnormalities are a major cause of IVF failure, implantation issues, and miscarriage. As maternal age increases, the likelihood of aneuploid embryos rises, significantly reducing the chances of a successful pregnancy. Studies show that by age 40, more than 50% of embryos may be aneuploid, leading to lower implantation rates and higher pregnancy loss.

By screening embryos before implantation, PGT-A helps identify the healthiest embryos with the highest potential for a successful pregnancy.

How Maternal Age Influences Embryo Quality

One of the strongest predictors of embryo health is the age of the mother. As women age, the likelihood of producing aneuploid embryos increases.

Women under 35 have a higher percentage of euploid embryos (normal chromosome count).
By age 40, more than 50% of embryos may be aneuploid, reducing the chances of successful implantation.
Women over 42 have an even higher risk, which significantly affects their IVF outcomes.

This is why PGT-A plays a crucial role in IVF success for older women, allowing fertility specialists to select embryos with the best genetic potential.

PGT-A vs. Other Genetic Testing: Which One Do You Need?

PGT-A is not the only genetic test available in assisted reproduction. Depending on the couple’s medical history, different types of preimplantation testing may be recommended:

Genetic Test	Purpose	Who Needs It?
PGT-A	Screens for aneuploidies (chromosome abnormalities)	Women over 35, recurrent miscarriage, previous failed IVF
PGT-M	Detects single-gene disorders (e.g., cystic fibrosis, sickle cell disease)	Couples with inherited genetic conditions
PGT-SR	Identifies chromosomal rearrangements (e.g., translocations, inversions)	Couples with a history of structural chromosomal abnormalities

Understanding the difference between PGT-A, PGT-M, and PGT-SR can help patients determine which genetic screening is most suitable for their IVF journey.

The PGT-A Process: What Happens Before Embryo Transfer?

Embryo Culture: After fertilisation, embryos develop in the laboratory for five to six days until they reach the blastocyst stage.
Embryo Biopsy: A few cells are carefully extracted from the trophectoderm (outer layer of the embryo) without harming development.
Genetic Analysis: The biopsied cells are tested for chromosomal abnormalities.
Embryo Selection: Only embryos with a normal chromosome count are chosen for transfer.

This method significantly increases IVF success rates by ensuring that only viable embryos are implanted.

How PGT-A Improves IVF Success Rates

Higher Implantation Rates: By selecting genetically normal embryos, the chances of implantation increase significantly.
Lower Miscarriage Risk: Aneuploid embryos often fail to develop or result in pregnancy loss.
Faster Time to Pregnancy: Couples can avoid multiple failed IVF cycles by transferring only viable embryos.

Who Should Consider PGT-A?

Women over 35: Higher risk of aneuploidy.
Couples with recurrent miscarriage: Often due to chromosomal abnormalities.
Patients with failed IVF: Even after transferring seemingly healthy embryos.
Carriers of genetic disorders: With potential chromosomal rearrangements.

For these groups, PGT-A can greatly improve the likelihood of a successful pregnancy.

Is PGT-A Right for You? Speak to a Specialist

PGT-A is a game-changing advancement in reproductive medicine, providing hope for couples seeking to improve their chances of a successful IVF cycle. Whether you are an older patient, have experienced failed pregnancies, or carry a genetic risk, PGT-A offers a scientifically backed approach to embryo selection.

To determine if PGT-A is the right choice for your IVF journey, consult with leading fertility specialists in Kuala Lumpur. Our experts are here to guide you through every step, ensuring the best possible outcome for your treatment. Contact our specialists today and take the next step toward parenthood.