Platelet-Rich Plasma (PRP) is widely used in orthopaedic and sports medicine as well as beauty treatments such as facial rejuvenation and hair restoration. In recent years, platelet-rich plasma (PRP) is being evaluated as a potential treatment for the two most difficult fertility issues: poor uterine/ endometrial lining and receptivity as well as low ovarian function.
What is Endo-PRP?
The endometrium plays a very important role during embryo implantation – a thicker endometrial lining is more likely to receives and provides greater nourishment for an embryo. Endo-PRP is a treatment that relies on your body’s own (autologous) blood plasma enriched with platelets, which contain large number of growth factors — to improve the odds of a successful pregnancy by thickening the endometrial lining, primarily in the treatment of recurrent implantation failure experienced over multiple IVF cycles.
PRP may be very helpful in cases of persistently thin endometrium before the embryo(s) are transferred inside the womb. The presence of chronic inflammation and scarring of the endometrium can make embryo implantation difficult in both natural pregnancy and IVF cycles. Endo-PRP aims to eliminate inflammation and promote the activity of the progesterone receptors that stimulate healthy growth of the endometrium.
Candidates for Endo-PRP
You may be eligible if you:
- have thin endometrial lining
- experienced two or more implantation failures (repeated implantation failure)
The Treatment Process
The process takes approximate 10 minutes and the infusion of the PRP in the endometrium is brief and painless.
Step 1: On the day of the therapy, the PRP process starts by a nurse drawing your blood (10ml) into a PRP blood tube.
Step 2: The blood is centrifuged for about 5-10 minutes.
Step 3: Embryologist will collect the plasma (now concentrated with platelets) in preparation for its infusion.
Step 4: Concentrated PRP will be infused into your uterine cavity with a catheter, and you will be allowed to rest 10-15 minutes post insertion.
How safe is PRP Treatment?
As your own blood (autologous) is used to obtain the PRP, no allergic reactions are expected.
Despite a large backing of current scientific literature, PRP is a treatment to consider alongside your fertility specialist in the treatment of recurrent implantation failure. PRP is still considered experimental and at the forefront of fertility treatment innovation, you are encouraged to discuss your options with our Fertility Specialists at Alpha IVF.
- Lin et al. Platelet-Rich Plasma as a Potential New Strategy in the Endometrium Treatment in Assisted Reproductive Technology. Front. Endocrinol 2021;12:707584
- Zamaniyan et al. Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial. Gynecological Endocrinology 2021;37(2):1-5
- Maleki-Hajiagha et al. Intrauterine infusion of autologous platelet-rich plasma in women undergoing assisted reproduction: A systemic review and meta-analysis. Journal of Reproductive Immunology 2020;137:1-9
- Samy et al. Effect of autologous platelet-rich plasma transfusion in the treatment of infertile women with thin endometrium and its implications in IVF cycles: a literature review. Middle East Fertility Society Journal 2020;25:5
- Wang et al. Investigation of platelet‐rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium. J Cell Biochem 2019;120:7403-7411
- Kim et al. Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study. Front Endocrinol 2019;10:61
- Nazari et al. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. International Journal of Reproductive BioMedicine 2016;14(10): 625-628